Welcome to the Mukhopadhyay group site! Some news from lab..

Always looking for postdocs and students with interest in microbial signaling and Host engineering. Contact Aindrila!

May 29th 2019

We engineered a fungal host, R. toruloides and optimized production condition to get > 85g/ L (for real) of a blue pigment Indigoidine. This compound is a non-ribosomal peptide. We are now exploring if R. toruloides is a good host for other NRPs – a large group of compounds ranging from commodity to fine chemicals. All this and sustainability!! Read Maren’s  open access paper here!

 

 

 

 

 

May 15th 2019

Our first paper on examining the impact of “JBEI” chemicals on biological systems is out! Robin and Thomas make a great team and we have fantastic cross-disciplinary contributors this story from across LBNL and also from external collaborators. We found that microbial presence does impact how plants respond to exposure to many chemicals. Check out the paper! More studies to follow and all in collaboration with the Mortimer group!!

 

 

 

 

 

 

 

May 3rd 2019

Very cool video of Ankita discussing Mercury as part of the #MyFavElement Series by Berkeley Lab! Check out the video here!

 

 

April 9th 2019

Lara’s paper is accepted! We have known since 2011 when we published our genome wide DAP-chip paper that the Lur Regulon in Desulfovibrio vulgaris is targeted by several two component systems. We now show how LurR regulates this operon. Rajeev et al 2019

April 5th 2019

We got a chance to present our Host Engineering thoughts, ideas and stories at the DOE JGI User meeting in San Francisco! What an amazing group of speakers to be part of!

 

 

March 12th 2019

Aindrila presents the Plasmidome story in the IGI Seminar series and answers some cool questions for Mira Cheng’s blog. Mentions of the awesome Esther Lederberg and Mary-Dell Chilton were very well received! We also presented this work at the Technology Mini Colloquia at the the DOE Annual meeting in San Francisco on April 2nd!

 

 

 

 

 

Feb 27th 2019

 

We engineered  Corynebactrium glutamicum to produce a pretty tidy level of isopentenol – a biofuel and a platform chemical. Great work by Yusuke Sasaki and Thomas Eng and the rest of the JBEI team! The paper is online and open access

 

 

Feb 26th 2019

Our discovery of large plasmids from the Oak Ridge FRC, spanning many incompatibility groups and many interesting functions is ONLINE!! Congratulations to Ankita Kothari and the team. Really pleased to have this out as it sets the stage for a lot more on this topic!

 

 

 

 

 

Feb 25th 2019

Our review on what we view to be challenges in engineering robust strains for large scale applications, and how Systems + Synthetic Biology can address them. Kudos to Maren for taking the lead on this! Read Online!!

Jan 17th 2019

2018 ended well for our team. We started the new year with the very first M-group retreat at the UC Faculty Club. It was a really fun day with interesting discussions on science, careers and some very fun team activities!

 

 

 

 

 

 

 

 

Dec 14th 2018

We published Maren’s study in characterizing the correct conditions required to produce the blue pigment Indigoidine in yeast. Also the first demonstration of this NRPS in Saccharomyces cerevisiae! Check out the paper

Dec 7th 2018

Congratulations to Jadie and Albert and their mentors Maren and Ankita for winning the  best poster and best presentation competition. A special thanks to Drishti for her very cool poster also! And a shout out to the JBEI and ENIGMA projects!!

 

Oct 13th 2018

Our paper examining the role of an essential gene in improving not only tolerance but also restoring production levels in the presence of biomass pretreatment reagents is out in Microbial Cell Factories!! Check out the Open access paper here!

Jul 11th 2018

Proud of these two bright researchers going off to grad school this fall. Congratulations to Jess and Robin on their acceptance to Riverside and Cal!

Jan 17th 2018

Our study on two component signaling cross-regulation is out in Molecular Microbiology! We used the DAP-seq method that Megan has developed and presented at the recent Gordon Research Conference. Congratulations to Megan and the whole team!

Dec 8th 2017

Read Maren’s interview with BD Biosciences about the Accuri!

Nov 9th 2017

Our one pot jet-fuel research got a mention in a popular science book! Woo hoo! Thanks to Kelly Weinersmith!

Oct 30th 2017

We published our paper in developing a synthetic transcriptional factor – hybrid promoter library for use in S. cerevisiae strain engineering.

Oct 12th 2017

Our study on improving membrane protein expression using genome wide edits is out in Scientific Reports!

July 17th 2017

DOE announces funding for JBEI other BRCs! Looking forward to many more years of research with a great team!

 

April 28th 2017


Duy presented her undergraduate work at the JBEI undergraduate Seminar! We loved having her in our group, and her research with Lara and Megan focused on understanding copper responsive systems in denitrifying Pseudomonads. She is a master of RNAseq preps! Congratulations on a great talk Duy!!

 

March 8th 2017


Ankita’s study on native plasmids from the Oakridge FRC is now online at BioRxiv!

 

Jan 19th 2017


Aindrila’s perspective on the future of microbial biofuel production in Biofuels International

Jan 5th 2017


Victor’s paper on Engineering glucose metabolism of Escherichia coli under nitrogen starvation is out in Nature Systems Biology and application.

 

November 27th 2016


Our Cas9 toolkit for yeast is now published online. Read about it on Today at Berkeley Lab. All the plasmids are available from Addgene!

 

 

May 10th 2016


Marijke’s paper on combining Ionic Liquid tolerance with biojet-fuel production is our in Green Chemistry and has a great write-up on Today at Berkeley Lab!

 

 

 

We lost a year of m-group news updates to grant writing…we may or may not be able to catch-up. But research was good and we published a lot!

 

August 17, 2015

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Lara’s paper out in JBact. We described the role of a two component system in nitrite stress in the obligate anaerobe Desulfovibrio vulgaris. 

 

July 3, 2015

Left to Right; Daniel, Luisa, Rob, Marijke, Victor, Jack, Marimikel, Heather, Megan, Amanda, Whitney, Ankita, Christa, Chuhui and Lara
Left to Right; Daniel, Luisa, Rob, Marijke, Victor, Jack, Marimikel, Heather, Megan, Amanda, Whitney, Ankita, Christa, Chuhui and Lara

The whole group at Bucci’s with all our visiting scientists and students (and the Bucci dog).

 

May 1, 2015

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Victor’s study on a Limonene tolerant AhpC mutant is out in AEM. A good explanation for why Limonene is so much more toxic than other similar monoterpenes. Congratulations to Victor, Florence and the rest our team!!

 

April 17, 2015

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Michela was part of our team that published two studies on D. vulgaris last year, one on motility genes and the other on cyclic-di-GMP signalling. Proud of Michela Catena who is going to travel to India this fall on a Fullbright Scholarship!! Congratulations Michela!

 

Jan 20, 2015

The Total efflux pump team: Angelique, Melissa, Florence, Aindrila and Camille (Missing Kat and Eric)
The Total efflux pump team: Angelique, Melissa, Florence, Aindrila and Camille (Missing Kat and Eric)

Flo’s paper is out in Biotechnology and Bioengineering A heroic effort in generating an improved pump for a volatile organic compound. We will look to the metabolic engineering community for a hexene production strain to implement this discovery.

 

Nov 4, 2014

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Jensen, Foo et al 2014 gets a nice write up by Lynn Yarris and was featured on the front page of the DOE webpage!

We published our study on improving Isopentenol tolerance and production in the mBio journal. mBio featured it in their blog. We have gotten many more mentions (RDmag, Science Daily, Green car congress…). Congratulations to Heather, Jee Loon and the rest of the team!!

 

Feb 26, 2014

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KQED QUEST Career spotlight video

 

June 6, 2013

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Lara’s Microcoleus Desert soil crust paper in online in the ISME Journal! And we get a wonderful article in TABL by Lynn Yarris.

 

May 13, 2013

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We get a chance to talk about our research at the Berkeley Rep at the Science at the theater organized by Friends of the Berkeley Lab!

 

March 19, 2013

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We get a mention in the Department Of Energy feature on STEM profiles.

 

Oct 1, 2012

Left to Right: Kavya, Melissa, Nhat-Tan, Lara, Marijke, Camille, Florence, Jee-Loon, Aindrila, Eric, Heather, Zain and Amanda
Left to Right: Kavya, Melissa, Nhat-Tan, Lara, Marijke, Camille, Florence, Jee-Loon, Aindrila, Eric, Heather, Zain and Amanda

The whole group at the Can’t Fail cafe. We have new members in the group – Amanda Reider Appel and Nhat Than Vuong!

 

Feb 14, 2012

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Science Today, a UC Berkeley Radio channel, features comments on our study of the D. vulgaris two component system regulator network.

 

Nov 9, 2011

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Lara and Eric’s Response Regulator Map paper gets written about in Berkeley Lab’s TABL site.

 

Oct 15, 2011

Lara at the Soil crust display at the Berkeley Lab open house
Lara at the Soil crust display at the Berkeley Lab open house

Lara and Eric’s D. vulgaris Response Regulator map paper is out in Genome Biology.

 

Sept 27, 2011

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Photo by Roy Kaltschmidt

Mario (in the blue lab coat) features in the Berkeley Lab news letter TABL for his important contribution in developing Bisabolene production in yeast. Here is a link to Pamela and TaekSoon’s Nature Communications paper

 

August 22, 2011

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Zain, Heather and Aindrila feature on the cover of the Biorefining magazine. Here is the article.

 

July 1, 2011

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Our efflux pump paper gets a mention in the Microbe magazine. Other mentions of our study are in eureka alert, techblog, science daily, microbeworld, Materials Today to list a few!

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